Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin.
We induced acute myocardial infarction (AMI) in mice to investigate the impact of allicin, a key component of garlic, on heart health. Over 28 days, we administered allicin orally while monitoring various factors such as heart function and inflammation through echocardiography and other tests.
Our findings revealed that allicin significantly eased myocardial injury, reducing markers of inflammation and improving heart function. It did this by inhibiting certain pathways associated with inflammation and remodeling gut microbiota, which plays a role in overall health.
Essentially, we found that allicin not only supports heart recovery but also enhances intestinal barrier health and improves metabolic balance. This discovery opens up exciting avenues for allicin to be considered as a supplementary treatment alongside conventional therapies for heart attacks.
Read More
9
Garlic compounds improve heart health
Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats.
We investigated how garlic oil (GO) and its active compound, diallyl disulfide (DADS), might protect the heart when used alongside carvedilol (CAR) in a study involving rats with induced heart damage. The experiment included different groups of rats that received GO, DADS, or CAR only, or a combination of these treatments, while being subjected to isoprenaline injections, which are known to cause heart issues.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
Read More
Most Useful Reviews
9
Reduced calcium deposits
34 people found this helpful
I have been taking garlic extract capsules for three years since my diagnosis with calcification of the heart valves. An ultrasound after 18 months showed a decrease in calcium deposits. I take 2 capsules twice a day, and it supports not just my cardiovascular system but also my immunity during the pandemic. I hope my experience is helpful.
Read More
9
Copes with hypertension
19 people found this helpful
My spouse switched to aged garlic after years of ineffective hypertension treatment with synthetic drugs. After four months, we noted no more high blood pressure episodes without medication, even after multiple flights. Cholesterol levels also improved. It’s easy to take, with no adverse effects.
Read More
9
Improved cardiovascular health
7 people found this helpful
My husband has benefitted greatly from garlic, improving his cardiovascular health. It has lowered his bad cholesterol and increased energy levels, reducing shortness of breath and fatigue. We whole-heartedly recommend this product!
Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats.
We investigated how garlic oil (GO) and its active compound, diallyl disulfide (DADS), might protect the heart when used alongside carvedilol (CAR) in a study involving rats with induced heart damage. The experiment included different groups of rats that received GO, DADS, or CAR only, or a combination of these treatments, while being subjected to isoprenaline injections, which are known to cause heart issues.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
Read More
8
Garlic's allicin aids heart recovery
Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin.
We induced acute myocardial infarction (AMI) in mice to investigate the impact of allicin, a key component of garlic, on heart health. Over 28 days, we administered allicin orally while monitoring various factors such as heart function and inflammation through echocardiography and other tests.
Our findings revealed that allicin significantly eased myocardial injury, reducing markers of inflammation and improving heart function. It did this by inhibiting certain pathways associated with inflammation and remodeling gut microbiota, which plays a role in overall health.
Essentially, we found that allicin not only supports heart recovery but also enhances intestinal barrier health and improves metabolic balance. This discovery opens up exciting avenues for allicin to be considered as a supplementary treatment alongside conventional therapies for heart attacks.
Read More
User Reviews
USERS' SCORE
Good
Based on 53 Reviews
8.1
All Reviews
Positive Reviews
Negative Reviews
9
Reduced calcium deposits
34 people found this helpful
I have been taking garlic extract capsules for three years since my diagnosis with calcification of the heart valves. An ultrasound after 18 months showed a decrease in calcium deposits. I take 2 capsules twice a day, and it supports not just my cardiovascular system but also my immunity during the pandemic. I hope my experience is helpful.
Read More
9
Copes with hypertension
19 people found this helpful
My spouse switched to aged garlic after years of ineffective hypertension treatment with synthetic drugs. After four months, we noted no more high blood pressure episodes without medication, even after multiple flights. Cholesterol levels also improved. It’s easy to take, with no adverse effects.
Read More
9
Improved cardiovascular health
7 people found this helpful
My husband has benefitted greatly from garlic, improving his cardiovascular health. It has lowered his bad cholesterol and increased energy levels, reducing shortness of breath and fatigue. We whole-heartedly recommend this product!
Read More
7.5
Maintains arterial health
7 people found this helpful
My father had open-heart surgery and suffered from clots. Since starting garlic two months ago, I’ve noticed remarkable improvement in his arterial health, allowing us to reduce his aspirin intake. I am thrilled with the results!
Read More
9
Improved circulation
6 people found this helpful
My father, who is diabetic and has clogged arteries, has been using this daily with COQ10. He feels more active, and the numbness in his legs and hands has significantly reduced. His doctor is pleased with the improvement in his cardiovascular health.
A heart attack, also known as myocardial infarction, occurs when blood flow to a part of the heart is blocked, often by a blood clot. This interruption can damage or destroy part of the heart muscle, leading to serious health complications or death if not treated promptly. Common symptoms include chest pain, shortness of breath, nausea, and lightheadedness. Risk factors include high blood pressure, high cholesterol, smoking, diabetes, and a sedentary lifestyle.
Preventing a heart attack largely revolves around maintaining a heart-healthy lifestyle. Regular exercise, a balanced diet rich in fruits, vegetables, whole grains, and lean proteins, along with managing stress, can significantly lower the risk. Furthermore, understanding your personal risk factors and engaging with healthcare professionals for regular check-ups can be crucial in both prevention and early detection. If you suspect someone is having a heart attack, it's important to call emergency services immediately, as timely treatment is vital for survival and recovery.
Garlic, scientifically known as Allium sativum, is a popular culinary ingredient that is renowned for its distinctive flavor and numerous health benefits. Belonging to the onion family, it is closely related to leeks and shallots. Garlic is typically used in various cuisines worldwide, lending its pungent, savory notes to a range of dishes from pasta sauces to roasted meats. Whether consumed raw, sautéed, or roasted, garlic not only enhances the taste of food but is also prized for its potential health properties, including its antimicrobial effects and ability to boost the immune system.
In addition to its culinary uses, garlic is often celebrated in alternative medicine for its health benefits. It is rich in essential nutrients, including vitamins C and B6, manganese, and selenium. Furthermore, research suggests that garlic may help lower blood pressure, improve cholesterol levels, and provide antioxidant effects. When buying garlic, opt for firm, dry bulbs with tight skin and avoid any signs of sprouting or softness. Fresh garlic cloves can easily elevate your cooking game, making them a staple in kitchens around the globe.
Garlic has long been celebrated for its potential health benefits, especially when it comes to heart health. Various studies suggest that garlic may help to lower blood pressure and improve cholesterol levels, both of which are significant risk factors for heart disease and heart attacks. The active compounds in garlic, such as allicin, are believed to contribute to these cardiovascular benefits by helping to relax blood vessels and reduce inflammation. While garlic can be a healthy addition to your diet, it's essential to view it as part of a comprehensive approach to heart health, which includes a balanced diet, regular physical activity, and other lifestyle changes.
However, it's important to note that while garlic may support heart health, it should not be relied upon as a sole treatment or prevention strategy for heart attacks. Always consult with a healthcare professional for personalized advice, especially if you have existing health conditions or are on medication. While the incorporation of garlic can be a flavorful and healthful addition to your meals, it should be part of a well-rounded diet and not a substitute for proven medical treatments.
Based on user reviews, many have reported varying timelines for experiencing positive effects from garlic supplements. For example, one reviewer noted significant improvements in arterial health and a reduction in medication after just two months of use Read Review. Similarly, another user observed a marked reduction in blood pressure and overall health improvement within four months Read Review. In contrast, some users have experienced benefits that took longer to manifest, with one individual witnessing improvements after 18 months of consistent use Read Review.
It’s important to note that individual results can vary widely and may depend on factors like existing health conditions and overall lifestyle. A few users even reported that their symptoms stabilized significantly after a few weeks, while others felt confident in the benefits of the supplement after many months Read Review. Therefore, while some users see improvements relatively quickly, others may need to continue the supplement for a longer period to experience its full benefits for heart health.
Recent studies highlight the potential heart health benefits of garlic, particularly its active compounds such as allicin and diallyl disulfide (DADS), in the context of heart attack recovery and protection. One study demonstrated that allicin significantly lessened myocardial injury in mice, reducing markers of inflammation and improving heart function during recovery following induced myocardial infarction. The research suggests that allicin can enhance heart recovery and overall health, opening avenues for its use as a supplementary treatment alongside traditional therapies for heart attacks [1].
Another study evaluated the effects of garlic oil and DADS in conjunction with carvedilol, a standard heart medication, on rats with heart damage. The findings indicated that combining these garlic compounds with carvedilol not only improved heart health but also increased antioxidant activities and decreased harmful cardiac enzymes and inflammatory markers. This complementary effect illustrates garlic's potential role in cardioprotection, especially when paired with established heart medications [2]. Overall, the emerging research supports the consideration of garlic supplements as beneficial options for heart health and recovery post-heart attack.
Users have reported a range of improvements in their cardiovascular health after incorporating garlic supplements into their routines. Many have noted significant reductions in blood pressure, with one individual highlighting that their spouse experienced no hypertension episodes after switching to aged garlic, even during stressful situations like flying Read Review. Others have observed marked enhancements in overall well-being, such as increased energy levels and less fatigue Read Review. Users attributed these positive changes to improved blood circulation, decreased cholesterol levels, and a robust immune system response, which they find particularly beneficial during health crises, such as the pandemic Read Review.
Several reviewers noted that garlic intake resulted in stabilized symptoms related to pre-existing heart conditions. For instance, one individual claimed their father, suffering from clogged arteries, experienced significant reductions in numbness in his extremities and increased daily activity after adding garlic to his regimen Read Review. However, it's important to bear in mind that individual experiences vary widely; some users expressed uncertainty regarding the specific impact garlic had on their cholesterol levels but still felt positive effects on their cardiovascular health Read Review. These anecdotal reports underline the potential benefits of garlic supplements, although personal health responses are not uniform.
Based on user reviews, many individuals have reported positive experiences when combining garlic supplements with other dietary supplements for managing heart health. For instance, one user indicated that their father, who has clogged arteries and diabetes, experienced significant improvements while taking garlic alongside COQ10. This combination not only made him feel more active but also reduced numbness in his extremities, which pleased his doctor Read Review. Another review highlighted that after years of cardiovascular issues and multiple heart attacks, a grandmother felt better after taking garlic, suggesting that it can be effective when used in conjunction with other treatments Read Review.
Additionally, users noted that incorporating garlic into their routines worked well alongside standard medical treatments. For instance, one reviewer remarked on significant cardiovascular improvements seen in their father following open-heart surgery and the use of garlic, allowing for a reduction in prescribed aspirin Read Review. Collectively, these accounts underscore the perceived benefits of combining garlic supplements with other heart health strategies, highlighting a potential synergy that users find useful for their individual health concerns.
Users report various dosing strategies for garlic supplementation, particularly in relation to heart health. A common recommendation is taking two capsules twice daily, as noted by a user who experienced decreased calcium deposits in heart valves after consistent use over 18 months Read Review. Others emphasize the benefits of aged garlic, indicating improvements in blood pressure and cardiovascular health after four months of use, suggesting that different forms of garlic might have varying effects and dosages Read Review.
Some users have reported taking anywhere from 6 to 10 capsules daily, particularly noting successful reductions in cholesterol and triglycerides Read Review. It's also advised to monitor individual reactions, since while one user found no benefit, others assert that garlic helped manage high blood pressure effectively Read Review. Overall, while there seems to be a consensus on garlic's positive impact on cardiovascular health, individual responses to dosage may vary significantly, highlighting the need for personalized recommendations.
7.5
Maintains arterial health
7 people found this helpful
My father had open-heart surgery and suffered from clots. Since starting garlic two months ago, I’ve noticed remarkable improvement in his arterial health, allowing us to reduce his aspirin intake. I am thrilled with the results!
9
Copes with hypertension
19 people found this helpful
My spouse switched to aged garlic after years of ineffective hypertension treatment with synthetic drugs. After four months, we noted no more high blood pressure episodes without medication, even after multiple flights. Cholesterol levels also improved. It’s easy to take, with no adverse effects.
9
Reduced calcium deposits
34 people found this helpful
I have been taking garlic extract capsules for three years since my diagnosis with calcification of the heart valves. An ultrasound after 18 months showed a decrease in calcium deposits. I take 2 capsules twice a day, and it supports not just my cardiovascular system but also my immunity during the pandemic. I hope my experience is helpful.
7.5
Improved heart health
23 people found this helpful
I have been taking garlic for several years. After two months, my doctor noted significant improvements in my health after my severe heart attack in 1988. I will be 92 next June.
9
Improved cardiovascular health
7 people found this helpful
My husband has benefitted greatly from garlic, improving his cardiovascular health. It has lowered his bad cholesterol and increased energy levels, reducing shortness of breath and fatigue. We whole-heartedly recommend this product!
9
Improved circulation
6 people found this helpful
My father, who is diabetic and has clogged arteries, has been using this daily with COQ10. He feels more active, and the numbness in his legs and hands has significantly reduced. His doctor is pleased with the improvement in his cardiovascular health.
2
No impact noted
4 people found this helpful
I did not find this supplement helpful for my high cholesterol; in fact, my levels increased. However, I prefer to believe there may have been some positive effect on my cardiovascular system, as my heart ultrasound showed everything is fine.
9
Grandmother improved
1 people found this helpful
I’ve been giving this to my grandmother after her two heart attacks. After four months, she feels much better and will continue to take it regularly.
9
Lowers cholesterol
22 people found this helpful
This garlic supplement is a fantastic natural alternative to reduce cholesterol and triglycerides. After weeks of taking 6 to 10 capsules daily, my levels dropped to the normal range, astonishing my doctor. I highly recommend this product for those with high lipid profiles.
7.5
Relieved symptoms
4 people found this helpful
Suffering from untreated high blood pressure, I tried Kyolic while awaiting a doctor's appointment. It proved to be a life saver—my headaches and fast heart rate have vanished. I’ll continue taking 1200 mg daily while monitoring my blood pressure.
8
Garlic's allicin aids heart recovery
Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin.
We induced acute myocardial infarction (AMI) in mice to investigate the impact of allicin, a key component of garlic, on heart health. Over 28 days, we administered allicin orally while monitoring various factors such as heart function and inflammation through echocardiography and other tests.
Our findings revealed that allicin significantly eased myocardial injury, reducing markers of inflammation and improving heart function. It did this by inhibiting certain pathways associated with inflammation and remodeling gut microbiota, which plays a role in overall health.
Essentially, we found that allicin not only supports heart recovery but also enhances intestinal barrier health and improves metabolic balance. This discovery opens up exciting avenues for allicin to be considered as a supplementary treatment alongside conventional therapies for heart attacks.
9
Garlic compounds improve heart health
Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats.
We investigated how garlic oil (GO) and its active compound, diallyl disulfide (DADS), might protect the heart when used alongside carvedilol (CAR) in a study involving rats with induced heart damage. The experiment included different groups of rats that received GO, DADS, or CAR only, or a combination of these treatments, while being subjected to isoprenaline injections, which are known to cause heart issues.
After 14 days, our results revealed that rats treated with any combination of GO, DADS, and CAR showed improved heart health. Specifically, we found that these treatments led to increased antioxidant enzyme activities, which support heart function, and a decrease in harmful cardiac enzymes and inflammatory markers in the blood. Moreover, the presence of carvedilol seemed to enhance the positive effects of garlic treatments, suggesting a possible teamwork between these substances in providing heart protection.
While both GO and DADS demonstrated nearly equal effectiveness, it was clear that using them with carvedilol supported heart health even more robustly. These findings suggest that garlic and its compounds can contribute significantly to cardioprotection, especially when combined with established heart medications like carvedilol.
References
Gao Y, Qin G, Liang S, Yin J, Wang B, et al. Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin. Drug Des Devel Ther. 2025;19:771. doi:10.2147/DDDT.S504884
Asdaq SMB, Alamri AS, Alsanie WF, Alhomrani M. Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats. Molecules. 2021;26. doi:10.3390/molecules26175137